Cancer is one of the leading causes of death worldwide and is characterized by uncontrolled proliferation and spread of abnormal cells. The loss of control over proliferation is brought about by mutations in genes involved in signalling pathways that regulate cell fate. Modern methods of cancer drug discovery involve identifying and targeting proteins whose deregulation leads to cancer. My work has been focused on understanding signalling pathways that regulate human disease including cancer and identifying novel compounds that target proteins required for cancer cell proliferation. My current work at SBASSE focuses on three main areas

1. Identification of novel synthetic and natural compounds for their anti-proliferative activity against cancer cell lines and understanding their mechanism of action. This work involves collaboration with chemistry department at SBASSE.
2. Identification of novel drug targets by hypothesis based compound library screening.
3. Understanding the mechanism of cancer drug resistance and to devise strategies to overcome such resistance